Computational analysis of 5-fluorouracil anti-tumor activity in colon cancer using a mechanistic pharmacokinetic/pharmacodynamic model
Fig 5
The simulation result of resistance analysis.
The first column is the time profiles of tumor volume; second column, 5-FU anabolites, third column: 5-FU induced DSB. Each row represents each aforementioned scenario. Red dash-dotted line, model simulation of resistant LS174T xenograft tumor; blue solid line: model simulation of sensitive LS174T xenograft tumor; yellow dashed line, the mean time course of 500 computed time courses; Θclosest denotes the parameter set associated with the time course of tumor volume closest to the tumor resistance response; purple dotted line: the time course generated by Θclosest.