Computational analysis of 5-fluorouracil anti-tumor activity in colon cancer using a mechanistic pharmacokinetic/pharmacodynamic model
Fig 3
Time profiles of intermediate components in cellular model.
(A) 5-FU in interstitial fluid, (B) intra-cellular 5-FU, (C) 5-FU anabolites, (D) F-RNA, (E) F-DNA, (F) % Free TS, (G) dUMP, (H) dNTP pool imbalance, (I) double-strand break generation. Red curve, model simulation; solid blue circle, literature data points; and error bar represents standard errors. The shaded areas represent the 0.7 credible regions.