Computational analysis of 5-fluorouracil anti-tumor activity in colon cancer using a mechanistic pharmacokinetic/pharmacodynamic model
Fig 2
Model simulation of 5-FU concentration in central and peripheral compartment.
Blue solid circle represents literature data; red solid curve, time profile of 5-FU in central plasma; yellow dash-dotted curve, the time profile of 5-FU in peripheral compartment. black dashed line: 0.7 credible regions of model simulation of central compartment; black dotted line: 0.7 credible regions of model simulation of peripheral compartment.