Dopamine depletion leads to pathological synchronization of distinct basal ganglia loops in the beta band
Fig 11
Effects of activity manipulations on network dynamics.
All manipulations are based on the opto-genetic stimulations discussed in [49]. OFF values are measured in pathologic conditions (Complete Model with Dd = 1.03) while ON values are measured when the opto-genetic perturbations are applied. (A) Simulated effects of motor cortex opto-inhibition on STN discharge rate (left) and intensity of β oscillations (right) (see also Figs 1k-l and 1i-j in [49]). (B) Predictions of the model on the intensity of β activity as a consequence of large variations of the STN discharge rate (see also Figs 2e-f-g and 5i-k in [49]). (C) Consequences of GPe opto-inhibition on GPe-TI and GPe-TA nuclei (first panels on the right) and predictions of the model on the effects of GPe opto-inhibition on STN discharge rate and intensity of β oscillations (right panels) (see also Figs 4k-l and 4i-j in [49]). Shaded areas in the plots reporting β intensity correspond to the values of observed for low Dd in the Complete Model (see Fig C in S1 Text).