Dopamine depletion leads to pathological synchronization of distinct basal ganglia loops in the beta band
Fig 9
Effects of Dopamine Depletion Dd on the Complete Model.
(A) Schematic representation of the Complete Model: the targets of Dopamine modulation are highlighted. (B) Mean frequencies of STN (blue) and D2 (red) nuclei as function of dopamine modulation Dd: the two mean frequencies converge due to the increase of Dd. (C) Unbiased measure of the intensity of β activity as a function of Dd: note the remarkable growth of the intensity in the synchronous regime. (D) Unbiased measure of the intensity of the D2 β activity as a function of Dd for different values of the population size n: the intensity of β activity is preserved only in the synchronous regime. Analogous results about STN β activity are shown in Fig C in S1 Text.