Dopamine depletion leads to pathological synchronization of distinct basal ganglia loops in the beta band
Fig 8
Effects of Dopamine Depletion Dd on the Simplified Model (ε = 0.75).
(A) Schematic representation of the Simplified model in the interacting case: the targets of Dopamine modulation are highlighted. (B) Mean frequencies of STN (blue) and D2 (red) nuclei as function of dopamine modulation Dd: the two mean frequencies converge due to the increase of Dd. (C) Unbiased measure of the intensity of β activity as a function of Dd: note the remarkable growth of the intensity in the synchronous regime. (D) Unbiased measure of the intensity of the D2 β activity as a function of Dd for different values of the population size n: the intensity of β activity is preserved only in the synchronous regime. (E) Unbiased measure of the intensity of the D2 β activity as a function of Dd for n = 1 and n = 8 and comparison between the interacting (ε = 0.75, continuous lines) and non-interacting condition (ε = 0.00, dashed lines): the intensity of β activity is preserved if and only if the two oscillators are synchronized. These results are associated with the analogous shown in Fig B in S1 Text.