Dopamine depletion leads to pathological synchronization of distinct basal ganglia loops in the beta band
Fig 6
Effects of the coupling strength ε on the Simplified Model.
(A) Schematic representation of the Simplified Model: the modulation of the coupling strength between the STR and STN loops is obtained by varying the connection probabilities p(ε, S → T) = εp1,S→T (see Eq (2)) of inter-loops connections. (B) Mean frequencies of STN (blue) and D2 (red) nuclei as function of the coupling strength ε: the two mean frequencies converge due to the increase of the coupling strength between the two oscillators. (C) Unbiased measure of the intensity of β activity as a function of ε: note the remarkable growth of the intensity in the synchronous regime. (D) Unbiased measure of the intensity of the STN β activity as a function of ε for different values of the population size n: the intensity of β activity is preserved only in the synchronous regime. (E) Value of the STN-PSD nuclei computed at the natural frequency of the STR oscillator as a function of the coupling strength. These results are associated with the analogous shown in Fig A in S1 Text.