Dopamine depletion leads to pathological synchronization of distinct basal ganglia loops in the beta band
Fig 4
Effects of Dopamine Depletion Dd on the two independent oscillators.
(A) Schematic representation of the Simplified Model in the non-interacting case. (B) Mean frequencies of STN (blue) and D2 (red) nuclei as a function of dopamine modulation Dd: note that the two mean frequencies do NOT converge due to the increase of Dd. (C) Unbiased measure of the intensity of β activity as a function of Dd: note that the intensity of the D2 resonance grows for increasing values of Dd. (D-E) Unbiased measure of the intensity of β activity in D2 (D) and STN (E) as a function of Dd and for different sizes n of the populations.