CNAViz: An interactive webtool for user-guided segmentation of tumor DNA sequencing data
Fig 3
CNAViz provides the user with a variety of analysis tools and automated functions to help generate an accurate segmentation.
(a) Average silhouette coefficient bar plot. Above the bar plot, the average of the silhouette scores for each cluster is displayed. Average Euclidean distance bar plot. Displays the average inter-cluster distance of each cluster to the cluster selected in the drop-down above the plot. (b) Centroid Table, illustrating each cluster, and the RDR and BAF values defining each cluster’s centroid in each sample. In this pop-up, we also provide the user with the automated Merge function, which allows the user to set RDR and BAF thresholds per sample. Clusters whose centroids are closer than the user-defined thresholds will subsequently be merged. See Automation for further details. (c) The Absorb Bins pop-up allows the user to select “From” clusters and “To” clusters. All bins in the “From” clusters will be evaluated according to a user-defined threshold, and re-assigned to the closest legal “To” cluster. See Automation for further details.