DPCfam: Unsupervised protein family classification by Density Peak Clustering of large sequence datasets
Fig 3
General properties of Metaclusters.
A Cumulative Distribution Function (1-CDF) of MC (purple) and Pfam family (green) sizes. All 210,802 MCs have been considered, with the size of a MC equal the number of its seed sequences. Pfam families (v. 33) are all those in Uniref50 ∩ UniprotKB (18,189 total) and family size is the ‘full’ size, that is, not only considering Pfam seed sequences. Black line: best fit of MC’s CDF with a power-law (CDF exponent γ = −1.15, corresponding to an exponent of −2.15 of the Probability Distribution Function). In S3 Fig, we additionally plot the size of MCs/Pfam families as a function of their size rank. B: Venn diagram showing the percentage of Low Complexity MCs (green), Disordered MCs (red) and Coiled-Coil MCs (purple), respectively (see Methods for definitions). Note that, in this case, only MCs containing at least 50 seed sequences and with average length ≥ 50 are considered (46,828 total).