A mathematical model of potassium homeostasis: Effect of feedforward and feedback controls
Fig 9
Impact of muscle-kidney cross talk on K+ depletion.
Simulation results for K+ depletion experiments for the baseline model and muscle-kidney cross talk simulations (Case MKX-DT-sec and Case MKX-CD-reab). Potassium intake (ΦKin) is the same for all three simulation types (A). Note that Case MKX-CD-sec is not plotted since it had little impact from the baseline model results. Horizontal grey line shows normal range for plasma K+ concentration (C) and intracellular K+ concentration (E). CD: collecting duct, DT: distal tubule