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A mathematical model of potassium homeostasis: Effect of feedforward and feedback controls

Fig 7

Effect of feedforward and feedback controls.

Simulation results for plasma K⁺ concentration (B) and intracellular K⁺ concentration (C) for 10 days of normal K⁺ intake ((A);100 mEq/day, 3 typical meals) for the baseline model, baseline without gastrointestinal feedforward (GI FF) effect (γ_Kin = 1), baseline without the ALD effect on Na⁺-K⁺-ATPase uptake (ρ_al = 1), baseline model without insulin effect on Na⁺-K⁺-ATPase update (ρ_insulin = 1), and baseline model with all feedback effects off. Grey lines indicate normal range for K_plasma and K_IC.

doi: https://doi.org/10.1371/journal.pcbi.1010607.g007