A mathematical model of potassium homeostasis: Effect of feedforward and feedback controls
Fig 6
Feedforward and feedback response to a single meal.
Model simulation predictions for (A) effect of insulin concentration ([insulin]) on Na+-K+-ATPase K+ uptake, (B) aldosterone concentration effect on Na+-K+-ATPase K+ uptake, (C) gastrointestinal (GI) feedforward effect on distal tubule K+ secretion, and (D) aldosterone effect on distal tubule K+ secretion. The meal experiment occurs at 0 hours. Initial conditions are steady state with a fasting state set before the meal experiment. The yellow lines denote the K+ deficient meal (i.e., “Meal only” experiment); purple, only K+ ingestion (i.e., “KCl only” experiment); blue, meal with K+ (i.e., “Meal + KCl” experiment).