Identifying the genes impacted by cell proliferation in proteomics and transcriptomics studies
Fig 4
Proliferation signature in the context of drug treatment.
a) Enrichment of the proliferation signature in the proteomes of cells treated with Brefeldin A. Proteins were ranked by significance of down-regulation according to Ruprecht et al. [7] (q-value) (horizontal axis) and the vertical axis presents the cumulative number of signature genes for each cell line. “2030” and “2122” correspond to the NCIH-2030 and NCIH-2122 cell lines, respectively. b) Volcano plot for A549 cells treated with Brefeldin A. Proliferation signature genes are highlighted in orange. The dashed line corresponds to a q-value of 0.05. c) Enrichment of the proliferation signature in the proteomes of cells treated with Docetaxel as in (a). d) Volcano plot for A549 cells treated with Docetaxel as presented in (b). e) Significantly down-regulated proteins (grey square in (d)) are presented in a STRING network of functional associations (score ≥ 0.7). Proliferation signature genes are highlighted in orange. f) Enrichment of the proliferation signature in the proteomes of cells treated with Ribociclib as in (a).