Optimizing laboratory-based surveillance networks for monitoring multi-genotype or multi-serotype infections
Fig 4
Impact of the proportion of severe cases serotyped on mean absolute error (MAE) of the estimated serotype-specific incidence rate of (A) all HFMD cases and (B) severe HFMD cases. Colored lines are smoothed by Gaussian process models. Black dot and triangle represent the probabilities of severe cases being serotyped that lead to the lowest error in estimating serotype-specific incidence rate of all (dot) and only severe (triangle) HFMD cases; blue dot and triangle represent the optimal designs from GA.