Synaptic reshaping of plastic neuronal networks by periodic multichannel stimulation with single-pulse and burst stimuli
Fig 13
PMCS-induced network structures in which either all-but-one or only one synaptic population was up-regulated while all others were down-regulated.
A: Raster plot of simulated spiking activity of LIF neurons 1000 sec after onset of PMCS with burst stimuli with high intraburst frequency and short phase lags between subsequent subpopulations. B: Snapshots of simulated synaptic weight matrix after 1000 sec of stimulation (sim) and the corresponding theoretical prediction obtained from Eq 1 (theory). C: Schematic of stimulation-induced network structure (see caption of Fig 9 for symbols). A’-C’: Same as A-C but for single-pulse PMCS. One phase lag was chosen to be significantly smaller than the others in order to up-regulate only one population of synapses. Parameters: de = 1 (all panels). In panels A-C, we used Astim = 0.8, an intraburst frequency of 120 Hz, five pulses per burst, f = 5 Hz, and Δα1/2 = 0.1. In panels A’-C’, we used single-pulse stimuli with Astim = 0.4, a stimulation frequency of f = 10 Hz, and the phase lags Δα1 = 0.1 and Δα2 = 0.5.