Synaptic reshaping of plastic neuronal networks by periodic multichannel stimulation with single-pulse and burst stimuli
Fig 9
Periodic stimulation may either up-regulate or down-regulate all synapses depending on the employed type of stimuli.
A: Raster plot of simulated spiking activity for PMCS with Δα1/2 = 0 and burst stimuli with low intraburst frequency. The scale bar indicates a time window of 100 ms. Stimuli are illustrated by red blocks. B: Snapshots of the simulated synaptic weight matrix after 1000 sec of stimulation (sim) and the corresponding theoretical prediction obtained from Eq 1 (theory). C: Schematic of stimulation-induced network structure. Circles represent subpopulations one, two, and three. Dashed arrows illustrate down-regulated synaptic connections. A’-C’: Same as A-C but for burst stimuli with high intraburst frequency. Thick arrows in panel C’ illustrate up-regulated synaptic connections. Parameters: Astim = 0.8, f = 5 Hz, and de = 1 (all panels). An intraburst frequency of 60 Hz and five pulses per burst were used in panels A-C, and an intraburst frequency of 120 Hz and five pulses per burst were used in panels A’-C’.