Synaptic reshaping of plastic neuronal networks by periodic multichannel stimulation with single-pulse and burst stimuli
Fig 8
Decoupling effects of three PMCS patterns compared to decoupling by CRS RVS.
A: Raster plot of spiking activity of LIF neurons after 1000 sec of periodic stimulation (Δα1/2 = 0) using burst stimuli of three pulses per burst and an intraburst frequency of 60 Hz. Furthermore, snapshots of the synaptic weight matrix of the LIF network (sim) and the corresponding theoretical approximation obtained from Eq 1 (theory) are shown. Successful stimulation-induced decoupling led to synaptic weights that were close to zero (white). B, C: The mean synaptic weight after 20 sec and 1000 sec of periodic stimulation as function of the stimulation frequency, f, for single-pulse stimuli (1P) and burst stimuli with two (2P), three (3P), and four (4P) pulses per burst (see legend). Panels B and C show results for an intraburst frequency of 60 Hz (B) and 120 Hz (C), respectively. Markers show simulation results (averaged over five network realization) and curves theoretical approximations (Eq 4). Vertical lines mark the frequency of the synchronous rhythm prior to stimulation (red dashed line) and the set of stimulation parameters corresponding to the raster plot shown in panel A (colored dotted line), respectively. A’-C’ and A”-C”: Same as A-C but for PMCS with Δα1/2 = 0.5 (A’-C’) and Δα1/2 = 0.33 (A”-C”), respectively. (a’’’-c’’’): Similar plots for CRS RVS. Parameters: de = 1 (all panels). Astim = 0.8 for PMCS with burst and CR RVS with single-pulse and burst stimuli. Astim = 0.4 for PMCS with single-pulse stimuli (B, C, B’, C’, and B”, C”).