Synaptic reshaping of plastic neuronal networks by periodic multichannel stimulation with single-pulse and burst stimuli
Fig 6
Mean synaptic weight during single-pulse PMCS depends on pulse duration and stimulation frequency.
Theoretical predictions (color maps) obtained from Eq 4 after 20 sec and 1000 sec of PMCS are compared to simulation results for the LIF network model (filled circles). w0 = 0.38 is the mean synaptic weight prior to stimulation. Labeled columns show results for different stimulation frequencies: f = 10.0 Hz (A, D), f = 5.0 Hz (B, E), and f = 2.5 Hz (C, F). Rows show results for short pulses (de = 1, top) and long pulses (de = 20, bottom) (Methods). Simulated spike trains, snapshots of the connectivity matrix, and theoretical predictions of the block structure of the synaptic weight matrix are shown below for the parameter sets marked by red crosses (see red figure labels). Parameters: Astim = 0.4.