Synaptic reshaping of plastic neuronal networks by periodic multichannel stimulation with single-pulse and burst stimuli
Fig 4
PMCS-induced network structure depends on phase lags and stimulus type.
Panels A-I show results for the PMCS pattern illustrated in panel A. Red rectangles mark stimuli. Individual stimuli were either charge-balanced single-pulse (D-F) or burst stimuli (G-I). B: Phase shifts, Δϕxy, between stimulus trains delivered to the postsynaptic subpopulation y and presynaptic subpopulation x. C: limt→∞〈wx → y(t)〉 obtained from Eq 1 for single-pulse stimuli (1P) and burst stimuli with three pulses (3P) (see panel I for color code). Panels D-F show a raster plot of simulated spiking activity of the LIF network model 1000 sec after stimulation onset (D), and snapshots of the network’s synaptic weight matrix taken 20 sec (E) and 1000 sec (F) after stimulation onset. After 1000 sec, acute effects of stimulation have fully developed. The scale bar refers to a 100 ms time interval. The block
of the synaptic weight matrix is marked red in panel F. G-I: Same as D-F but for burst stimuli with three pulses per burst and an intraburst frequency of 120 Hz. A’-I’: Same as A-I but for the PMCS pattern illustrated in panel A’. Parameters: f = 5 Hz; Astim = 0.4 (single-pulse stimuli) and 0.8 (burst stimuli), de = 1. Δα1/2 = 0.5 (A-I), and Δα1 = 0.1 and Δα2 = 0.3 (A’-I’).