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Synaptic reshaping of plastic neuronal networks by periodic multichannel stimulation with single-pulse and burst stimuli
Fig 2
Statistics of LIF neurons’ spiking responses to periodic delivery of single-pulse (top) and burst stimuli (bottom).
A: Raster plot of spiking activity of a network of 103 LIF neurons during periodic single-pulse stimulation (red bars) of 333 neurons. B: Mean number of spikes per ISI and neuron as function of the dimensionless stimulation amplitude, Astim, and pulse width, de (Methods). Gray contour lines correspond to 0.75 and 1.25 spikes per ISI and neuron (from bottom to top). C: Cumulative distribution function of the timing of the first spike of LIF neurons after stimulus delivery 
(Methods) for the stimulus parameters marked orange, black, and brown, respectively, in panel B. The inset zooms into the first 5 ms. The stimulation current, Istim, corresponding to de = 10 is shown in panel D. E: Same as A but for burst stimuli with five pulses per burst and an intraburst frequency of 120 Hz. F: Mean number of spikes per ISI and neuron as function of the number of stimulus pulses per burst and the stimulation amplitude. G: Cumulative distribution function of the timing of the kth spike per ISI 
for the parameter set marked white in panel F. Color code: F1(t) (black), F2(t) (blue), F3(t) (green), F4(t) (brown), and F5(t) (red). H: Corresponding stimulation current, Istim. Parameters: f = 5 Hz (all); Astim = 0.4, and de = 10 (A,C,D) and de = 1 (C, orange) and de = 20 (C, brown); and Astim = 0.8, de = 1, and 120 Hz intraburst frequency (E, F, G, H).
doi: https://doi.org/10.1371/journal.pcbi.1010568.g002