Utility of constraints reflecting system stability on analyses for biological models
Fig 7
Part of parameter sets obtained by TEAPS can reproduce the in vivo phenotype associated with the administration of NSAIDs.
(A, B) The situations where each NSAID was administered to suppress PGE2 levels in PMN to approximately 10% of control were compared with the previously reported article. Each blue point corresponds to a result by one parameter set obtained by TEAPS. Red asterisks indicate the reported values by the simulation results using the previously reported model. PGE2 level in PMN (A) and the ratio of PGI2 to TXA2 (PT ratio) (B), a marker of physiological output, are shown. (C) Patterning of pharmacological outputs by clustering analysis showed the difference of pharmacological actions. Clustering analysis was performed based on the pattern of the simulated PT ratios by the obtained parameter sets under each drug exposure. The COX-2 selectivity was figured out by the phylogenetic tree.