High-order functional redundancy in ageing explained via alterations in the connectome in a whole-brain model
Fig 4
Heterogeneity of the connectome degeneration.
A: The non-parametric Spearman’s rank-correlation r between age and individual weights wij of the SC matrix was calculated across all different participants (N = 161). The final number of weights that survived to multiple comparisons is represented in the right panel, with values ranging from -0.25 to -0.50. B: We built a new connectivity matrix using as links the absolute values of r obtained for each weight (left panel). Next, the Leuven community detection method was applied before correcting for multiple comparison and three main communities (center) were found. The links that belong to each community and that survived Bonferroni correction are also shown (right). As an illustration, we show one arbitrary link within each of these communities (colored in green and pink). Here, |r| denotes the absolute values of all elements of matrix r.