Identifying enhancer properties associated with genetic risk for complex traits using regulome-wide association studies
Fig 5
Features of brain-expressed enhancers associated with schizophrenia risk.
A) Risk-associated enhancers are in physical contact with gene sets previously implicated in risk for neuropsychiatric disorders. Shown here are gene sets with a median p-value across the 10 brain enhancer samples < 0.05. GWAS = genes at GWAS risk loci. Full description of gene lists available in Methods. B) Evolutionary conservation and AT-richness of enhancers were associated with schizophrenia risk. HGE/HAR status and distance to the nearest gene TSS were not associated with risk.