Mathematical modeling of plus-strand RNA virus replication to identify broad-spectrum antiviral treatment strategies
Fig 9
Relative virus decay under combination therapy that clears HCV, DENV, and CVB3 infections.
A combined drug effect on A) vRNA synthesis and formation of translation complex (TC), B) vRNA synthesis and translation, and C) viral RNA synthesis and polyprotein cleavage. Initiation of treatment was in steady state (100 h pi). The drug efficacy constant (εA and εB) were chosen as minimal efficacies to clear all three viruses. For comparability, virus-specific concentrations in steady state have been normalized to their virus-specific pre-treatment steady-state concentration. A successful drug treatment leads to more than 99% viral eradication (light yellow), while an ineffective drug treatment leads to 100% remaining virus (black).