Mathematical modeling of plus-strand RNA virus replication to identify broad-spectrum antiviral treatment strategies
Fig 8
Combined drug effect on A) vRNA synthesis and formation of translation complex (TC), B) vRNA synthesis and translation, and C) viral RNA synthesis and polyprotein cleavage. Initiation of treatment was in steady state (100 h pi). A successful drug treatment leads to more than 99% viral eradication (light yellow), while an ineffective drug treatment leads to 100% remaining virus (black).