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Mathematical modeling of plus-strand RNA virus replication to identify broad-spectrum antiviral treatment strategies
Fig 2
Best fit of the model to the data with standard deviation (left panel) and model prediction of plus-strand RNA allocation between the cytoplasm and replication organelle (RO) (right panel). For parameter values, see Table 2. [LEFT: green: (+)RNA = 
, red: (-)RNA = 
, blue: A) Virus = Vtot = VR, B) and C) Virus = Vtot = (V+VR), yellow: Luc = L; RIGHT: yellow: RNA in cytoplasm = 
, purple: RNA within replication organelle (RO) = 
; Infectious virus was measured in PFU/mL, (+) and (-)RNA were measured in molecules/mL or relative RNA concentration, luciferase was measured in relative light unit (RLU)].
doi: https://doi.org/10.1371/journal.pcbi.1010423.g002