Mathematical modeling to understand the role of bivalent thrombin-fibrin binding during polymerization
Fig 7
Fiprinopeptide cleavage and thrombin binding.
Three typed of fibrin(ogen) are considered: γ′/γ′ fibrinogen (blue), γA/γ′ fibrinogen (red), and γA/γA fibrinogen (yellow). Shown are time courses of (A) the percent of FpA (dashed lines) and FpB (solid lines) cleaved due in the presence of 0.1 nM thrombin and 0.1 mg/ml fibrinogen, (B) the percent of free thrombin, (C) the percent of thrombin bound to low-affinity binding sites (those not associated with bivalent binding), BE1 and BG, and (D) the percent of thrombin bound to high-affinity, bivalent sites: BE, BG, and B.