Mathematical modeling to understand the role of bivalent thrombin-fibrin binding during polymerization
Fig 5
Box plot of parameter estimates and relative clot time vs. fibrinogen.
Left: Box and whisker plot for 300 parameter sets with the smallest least squares errors from the parameter estimation process. The parameter values are shown in log-scale and the units are those in Table 2. Right: The ratio of clot times showing the relative clot time between γA/γ′ to γA/γA fibrinogen. Clot time being defined as the time to half-maximal turbidity measurement. The model output (solid line) is below the experimental data from Kim et al. [38] (dots with error bars).