A multi-objective based clustering for inferring BCR clonal lineages from high-throughput B cell repertoire data
Fig 9
Clonal distribution comparisons on three experimental repertoires.
We compared the inferred clonal lineages of each BCR lineage grouping tool with MobiLLe’s clustering results. For that, we defined five events: identical, join, split, mix, and not found, representing the (dis)similarities between two clonal distributions: d1 (MobiLLe) and d2 (another tool). The “identical” event accounts for the percentage of identical clonal lineages found in both distributions; the “join” event reports the percentage of d1 clonal lineages found merged in d2 while “split” the percentage of d1 clonal lineages found separated in d2. The “mix” event accounts for a mixture of “join” and “split” events while “not found” reports the percentage of clonal lineages in d2 not found in d1; see an illustration in Fig 2.