Rhythmicity is linked to expression cost at the protein level but to expression precision at the mRNA level
Fig 2
Among the factors of expression costs, expression level is the main factor explaining the higher cost observed in rhythmic proteins.
a) The total cost of rhythmic proteins is higher than those of other proteins. b) With the exception of mouse liver, rhythmic proteins do not contain more expensive amino-acids than other proteins. c) Rhythmic proteins can be longer in some species. d-e) Mean or maximum expression level calculated from time-series datasets: rhythmic proteins are highly expressed proteins. Boxplots are log scaled except for the averaged AA synthesis cost. The first 15% of proteins from p-values ranking (from the most rhythmic to the most un-rhythmic genes) obtained from the rhythm detection algorithms were classified as rhythmic.