Multiscale modelling of desquamation in the interfollicular epidermis
Fig 7
Simulation results for different proportions of normal stem cells (generate cells with normal inhibitor levels) to abnormal stem cells (generate cells with no inhibitor).
(A) Steady state corneum height. The points are the mean and the bars indicate the minimum to maximums for the 10 realisations of each setup. The solid line is a quadratic fit (equation given in legend), and the dotted line shows the expected results for a linear relationship. (B) Reactant levels of each cell at one time point with 50% normal stem cells and 50% abnormal (no) stem cells. The dashed line is the steady state height. The two paths for both s (red) and e (blue) are the different subcellular system dynamics for cells that have normal inhibitor levels (lower e and slower reduction in s) compared to cells with no inhibitor (higher e and faster reduction in s). (C) and (D) Simulation snapshots with cells coloured by their proportion of free enzyme, e (C) or proportion of remaining substrate, s (D). A video of this simulation can be found in S3 Video. (E) Cell velocities. The box plot shows the quartiles, and the error bars give the minimum and maximum across all cells and simulations. The velocity profile is similar across the different proportions. (F) Turnover times of differentiated cells. The box plot shows the quartiles, and the error bars give the minimum and maximum across all cells and simulations.