Diversity and evolution of computationally predicted T cell epitopes against human respiratory syncytial virus
Fig 2
Predicted T cell epitope landscapes and genetic evolution of RSV surface proteins.
Filled circles indicate RSV F protein isolates or G protein isolates without duplication. Diamonds indicate G protein isolates with gene duplication. (A) Epitope landscapes of RSV major surface proteins are built with MHC class I and class II epitope content comparison across different strains. T cell immunity clusters are determined with k-means method and are used to color the sequenced isolates in the following panels. (B) The corresponding time-scaled phylogenies are reconstructed with the Maximum Likelihood (ML) approach. (C) T cell epitope immune distance and (D) genetic hamming distance from the estimated TMRCA are plotted against the isolated time of each sequence.