Binding mechanism of oseltamivir and influenza neuraminidase suggests perspectives for the design of new anti-influenza drugs
Fig 4
Comparison of the conformations of sialic acid and oseltamivir at the secondary binding site.
The position outlined by the black dotted square in the left panel is the secondary binding site of NA. Emerald green in the right panel represents oseltamivir and NA in the simulation, and magenta represents sialic acid and NA in the crystal structure (PDB ID: 1MWE). Hydrogen bonds between sialic acid and partial residues in the secondary binding site are shown as dashed red lines.