Binding mechanism of oseltamivir and influenza neuraminidase suggests perspectives for the design of new anti-influenza drugs
Fig 3
Interaction of oseltamivir with NA in metastable S0-S9.
The position of the residue that participated in H-bond interactions with oseltamivir is marked with black dots. The red spheres in S8 and S9 represent the oxygen atoms of water molecules (the hydrogen atoms of water molecules are not shown), which participated in the formation of water-mediated H-bonds. The 150 loop, 370 loop and 430 loop regions are highlighted in pink, ice blue and green, respectively.