Detection of genes with differential expression dispersion unravels the role of autophagy in cancer progression
Fig 3
Differentially dispersed genes correctly identified by the evaluated methods among lowly differentially expressed genes.
(A) Intersections of sets of differentially dispersed (DD) genes correctly identified by Levene’s test, MDSeq, DiPhiSeq, GAMLSS and DiffDist. (B): Correctness of dispersion log2-fold change sign of DD genes correctly identified by the different methods. (C) Real mean and dispersion log2-fold changes and estimated dispersion log2-fold changes of DD genes correctly identified by GAMLSS and DiffDist. (D) Correctness of dispersion log2-fold change signs according to Levene’s test, MDSeq and DiPhiSeq for DD genes correctly identified by GAMLSS and DiffDist with incorrect dispersion log2-fold change sign. Simulated datasets are composed of lowly differentially expressed genes with a mean fold change of expression between 1 and 1.5 between two populations of 50 samples. Values indicated at the middle of the bars are percentages of the corresponding categories of genes over the entire sets of analyzed genes. All results relate to 10 replicates of simulated datasets, e.g. the counts and percentages are averaged over all the replicates.