Amyloid pathology disrupts gliotransmitter release in astrocytes
Fig 2
Description and characterization of the Ca2+-dependent gliotransmitter release machinery.
(A) Schematic of the gliotransmitter release machinery. (B) Pathways of release, endocytosis, and recycling of docked and mobile vesicles. (C) Vesicular release rate through Synaptotagmin 4 (Syt4) in response to a range of steady state Ca2+ concentrations. (D) Peak release rates of Syt4 are fitted to a Hill function to estimate the dissociation constant (kd). (E) Time to peak release rate of Syt4 decays exponentially with Ca2+ concentration. (F) Release rates of Synaptotagmin 7 (Syt7) in response to a range of steady state Ca2+ concentrations. (G) Peak release rates of Syt7. (H) Time to peak release rate of Syt7.