Thalamic deep brain stimulation paradigm to reduce consciousness: Cortico-striatal dynamics implicated in mechanisms of consciousness
Fig 6
MIP changes reflect switches in parieto-striatal association indicative of consciousness.
A, B, Probability (connection weight) of each brain area associating with any other on the same side of the MIP for states assumed to be (A) conscious (pre-VPC, post-VPC, resting wake (RW), fixation task (FX) and control stares) or (B) less conscious (VPC, propofol (Prop), or isoflurane (Iso)). C, D, Results (Z statistics ± SD of the null distribution) of the permutation test comparing cortico-striatal MIP associations under the null hypotheses that (C) MIP types occur randomly, or (D) MIP types reflect the same patterns as conscious states (defined by the resting wake and fixation task samples). Both approaches separate more conscious from less conscious states. E, Normalized Φ* (±SE) for VPC and control stares (STR) calculated in 1s sliding windows (.1s steps) and aligned to event onset (black vertical line). Horizontal pink line shows regions of significance for the pairwise t-test across time comparing VPC Φ* at each sample to the maximum. No significant differences were found in the control stare condition. F, Cortico-striatal significance (Z) based on the sliding window approach in E for VPC and stare conditions. Computations used the same approach as in C, but now for each sample in the sliding window.