Thalamic deep brain stimulation paradigm to reduce consciousness: Cortico-striatal dynamics implicated in mechanisms of consciousness
Fig 5
Measure of neural complexity and integration (Φ*) associated with consciousness selectively decrease during VPC, and integration patterns shift to reflect anesthetized rather than conscious states.
A, Average entropy (H) and B, Φ* (±SE) centered relative to the fixation task for VPC and control stares relative to pre and post event conditions. C, D, Average Φ* (±SE) for stim-off (gray bars) and stim-on (colored bars) epochs at different frequencies excluding VPC for resting wake (C) and fixation (D) controls. E, F, Gaussian kernel-density estimates fitted to the probability distribution for the occurrence of different MIP types of the full system for (E) pre, VPC, control stare (STR), post, (F) resting wake (RW), fixation (FX), isoflurane (Iso), and propofol (Prop) conditions. G, Results for the KS tests comparing the MIP kernel-density estimates across all conditions. Color scales with the strength of the KS stat. * indicates corrected p-value (pc) < .05.