Thalamic deep brain stimulation paradigm to reduce consciousness: Cortico-striatal dynamics implicated in mechanisms of consciousness
Fig 1
Structural imaging used to target multi-microelectrode DBS to the central lateral thalamus.
A: Schematic of coronal thalamic section (right hemisphere) with tailored DBS electrode placed such that contacts span the dorsal-ventral extent of CL (yellow). We simultaneously stimulated via 16 electrode contacts (200μm spacing between contacts), with the centermost contact (contact 8) shown in red. B: Track reconstruction of DBS sites overlain on the high-resolution structural image of the thalamus (monkey R, right hemisphere, A8). Only the centermost contact location shown (colored circles) for clarity. For each stimulation, 8 contacts above and 7 contacts below the colored circle would also be stimulated. To improve visualization by reducing overlap, positions plotted with up to 1 voxel (.5mm) jitter separately for 10, 50, and 200Hz experiments. Black lines demarcate different thalamic nuclei: central lateral, CL; centromedian, Cm; lateral dorsal, LD; lateral posterior, LP; mediodorsal, MD; parafascicular, Pf; ventral posterior lateral, VPL. Stimulation performed at all frequencies for most sites.