Single-cell network biology characterizes cell type gene regulation for drug repurposing and phenotype prediction in Alzheimer’s disease
Fig 3
Hierarchy analysis of cell type gene regulatory networks in AD.
(A) The distribution of TFs in three levels of hierarchy in AD, control and 1000 random GRNs across all four cell types. (B) The rewiring scores of TFs (x-axis) across all three levels of hierarchies (y-axis). The distributions of (C) number of promoters targeted by TFs (y-axis) and (D) the fold change values (log scale; y-axis) of target genes (AD versus healthy controls) of TFs at the three levels of hierarchy (x-axes). (E) Enrichment of gene ontology biological processes (y-axis) within targets of top, middle and bottom layers of the regulatory hierarchy across cell type networks (x-axis).