Random-effects meta-analysis of effect sizes as a unified framework for gene set analysis
Fig 2
Power on simulated data with small effect sizes.
A) LFC distributions in the inset (red) and outset (blue) for an example simulation. As in (Fig 1) the variance of the inset distribution was allowed to change, leading to simulations with different levels of enrichment for DE genes in the inset. The dashed lines show the location of the threshold (in this case a fold-change of 1.1) used to define differential expression. B, C) Sample sizes of 20 (B) or 40 (C) were simulated. The x-axis indicates the relative enrichment in the inset of the proportion of the LFC distribution beyond the upper or lower thresholds.