Cross-fitted instrument: A blueprint for one-sample Mendelian randomization
Fig 2
Power curves for CFMR versus two-sample MR (2SMR) using the simulation setup described in the Simulations section in the main text (with h2 = 20%).
The dashed lines represent power curves for CFMR, while the solid lines represent the theoretical power for 2SMR [24]. Note that the solid pink line covers the solid red line perfectly (top part of the graph). These lines fully overlap as a result of symmetry. Given that the solid lines are generated from the theoretical power formula of two-sample MR (see Deng et al. [24]), the red and pink curves correspond to the same effect size (in terms of magnitude) but have opposite signs. The same is the case for the solid blue and gold lines in the middle part of the graph.