Computational analysis of memory consolidation following inhibitory avoidance (IA) training in adult and infant rats: Critical roles of CaMKIIα and MeCP2
Fig 3
(A) Schematic model of the pathways that are blocked by PSI (red X’s). (B) Reduction of synaptic weight W at day 2 (blue curve) and 7 (red curve) after training, with the addition of PSI initiated at varying times. ‘1’,’2’,’3’ represent different phases. (C-D) Simulated reduction of W response to PSI in the absence of the BDNF-CaMKIIα feedback loop (C) or of the BDNF-C/EBPβ feedback loop (D) or of the downstream W loop (E) at day 2 (blue) and day 7 (red). Insert in (E), same as main panel except Y axis scale is expanded to more clearly illustrate vertical variations in W.