From affinity selection to kinetic selection in Germinal Centre modelling
Fig 4
OCs production and affinity maturation.
Results are obtained from 30 simulations. (A), (B) and (C) represent produced OCs from each clone in the reference scenario, Scenario-1 and Scenario-2, respectively. Each dot represents OCs produced in a single simulation. Red lines denote the average. (D), (E) and (F) represent the average affinity of living GC B cells (dashed lines) and the cumulative average of produced OCs (solid lines) belonging to each clone in the reference scenario, Scenario-1 and Scenario-2, respectively. Shaded areas indicate the maximum and minimum of OC’s average affinity in 30 simulations.