From affinity selection to kinetic selection in Germinal Centre modelling
Fig 3
Dynamics of population and Ag collection phase.
Results are obtained from 30 simulations. (A) The average of CB+CC counts for each clone in the reference scenario (Scenario-0). (B) Collected Ag for each clone during the GC reaction in the reference scenario. This consists of Ags collected by all CCs in each clone. Lines represent averages. The shaded area denotes the minimum and maximum values in all repeats. (C) Events during the Ag collection phase for CCs that attend the Tfh selection phase in the reference scenario. CC-FDC interactions denote the events at which the CC is located at an Ag binding site on a FDC. Boxplots are produced based on combined data of all simulations. Black dots represent average values per cell in each clone over all repeats. (D) The population of CCs that are positively selected by Tfh cells. Solid lines represent the average of all simulations. (E), (F), (G), and (H) represent the results of Scenario-1. (I), (J), (K) and (L) represent the results of Scenario-2. Panel descriptions are similar to that of the reference scenario.