CellDynaMo–stochastic reaction-diffusion-dynamics model: Application to search-and-capture process of mitotic spindle assembly
Fig 7
Influence of stochastic noise on dynamics of KT-MT attachments.
Comparison of the types and numbers of KT-MT attachment from the simulations with the random force component (shaded bars) and without random force component (blank bars) for: A) A single KT pair with the Phosphatase to Aurora B (P:AB) ratio = 1:10, B) A single CH with CH arms (see also Fig J in S1 Text). The KT-KT orientation angle vs. time (solid lines) and distance to the equatorial plate vs. time profiles (dashed lines) for the case of a single KT pair with P:AB ratio = 1:10 (panel C) and for a single CH with CH arms (panel D). Black lines in panel C corresponds to simulation run without thermal fluctuations and demonstrate amphitelic attachment. Red and blue lines correspond to simulation runs with thermal fluctuations and demonstrate monotelic and merotelic attachments, respectively. In panel D, black and green lines represent simulation runs without and with thermal fluctuations, respectively. Panels E and F demonstrate the profiles for the number of MTs attached to KTs from both CS for a single KT pair with P:AB ratio = 1:10 and for a single CH with CH arms, respectively. In panels E and F, the assignment of curve color is same as in panels C and D. Abbreviation L1, L2, R1, and R2 are same as in Fig 6D.