Deriving time-concordant event cascades from gene expression data: A case study for Drug-Induced Liver Injury (DILI)
Fig 11
Combining time dependence and concordance to identify mechanistically supported biomarkers.
A) The relation between time concordance, quantified by the enrichment p-value for event activation before adverse histopathology, and time dependence, quantified by the meta p-value for Spearman correlation between time and event activation across adverse conditions, is shown. B) For events with the most significant time-dependence, the distribution of correlation coefficients is shown providing further insight into the strength of correlation and consistency across adverse conditions.