Deriving time-concordant event cascades from gene expression data: A case study for Drug-Induced Liver Injury (DILI)
Fig 10
Causal relationships between TFs supported by time concordance.
For TFs which are significantly enriched before or at adverse histopathology, known causal relations are shown in which the upstream event is found before or at the downstream event in at least 20% of adverse cases. For induced TFs for which expression is found before regulon activity and significantly enriched, not only protein-protein interactions are considered but also upstream TF-target gene interactions annotated with DoRothEA [69] confidence scores (A: High confidence, C: Medium confidence).