Deriving time-concordant event cascades from gene expression data: A case study for Drug-Induced Liver Injury (DILI)
Fig 7
Temporal concordance of nuclear receptors and adaptive response transcription factors (TFs) in DILI.
For known TFs in DILI the following time concordance metrics are shown: A) The enrichment significance before or at first adverse histopathology, B) Positive Predictive Value (PPV) and True Positive Rate (TPR), C) Max. mean |logFC| before or at first adverse histopathology. As background distribution in grey, the statistics for all inferred TFs is shown.